ABSTRACT
Alzheimer's disease（AD） is an incipient aging neurodegenerative disease， which increases rapidly along with the development trend of social aging and seriously threatens the health of the people. In the absence of effective preventive measures， it will have an enormous impact on the socio-economic and healthcare system. The study found that abnormal cell signal transduction is a key link in many diseases. Cell signal transduction theory has been widely used to clarify the essence of traditional Chinese medicine visceral image and the mechanism of traditional Chinese medicine. 'Correlation of Liver and Kidney' is one of the core plates of the theory of 'Correlation of Five Organs'， which is suitable for explaining the pathogenesis of complex diseases and the correlation of multiple syndromes， and guiding the prescription of clinical syndrome. Hei Xiaoyaosan， as the first choice compound for the prevention and treatment of AD based on the theory of "Correlation of Liver and Kidney' in our team， can play the effects of prevention and treatment by soothing liver and nourishing blood， strengthening spleen and tonifying kidney， and promoting brain collaterals and dredging viscerab spirit. Based on the theory of 'Correlation of Liver and Kidney'， this paper expounds the pathogenesis of AD from the perspective of traditional Chinese medicine， and puts forward the methods and ideas of the preventing and treating of AD from Ca2+-calcium/calmodulin dependent protein （CaM）/calcium/calmodulin dependent protein kinaseⅡ（CaMKⅡ）-cyclic adenosine phosphate reactive element binding protein （CREB） cell signal transduction pathway by consulting literatures and previous studies.
ABSTRACT
Neurocysticercosis [NCC] is expected to be the most common parasitic disease of humans' central nervous system, immunological tests and epidermiological data as well as clinical manifestations and neuroimagings are helpful to make the diagnosis. We report a case of NCC in a buddust's cerebellar hemisphere, the indirect hemagglutination tests were negative, craniotomy was done and two transparent cysts with scolexes were removed, the patient was discharged with good outcome. Histological findings confirmed the diagnosis of NCC. NCC in cerebellar hemisphere is rare, it is more difficult to diagnose when immunological tests are negative, therefore, multiple tools are expected to develop diagnosis and evaluate the efficacy of treatment